Therapy

Cardiogenic shock
Cardiogenic shock remains a killer –and is still without an effective treatment method

“Cardiogenic shock – usually a consequence of left ventricular pump failure – is the most frequent cause of intra-hospital death following acute myocardial infarction. Between 5 and 10% of all patients suffering myocardial infarction will experience cardiogenic shock, either as an acute episode or in the following days. Cardiogenic shock resulting from myocardial infarction has a fatality rate of between 50 and 80% …”

“Infarction-induced cardiogenic shock is more than just heart disease! The multiple organ dysfunction syndrome (MODS) that presents concurrent to the state of shock determines the patient’s prognosis! Here it is imperative to treat the shock effectively and to provide myocardial infarction patients with ideal intensive care as soon as cardiogenic shock sets in.”

2010, Werdan et al, S3 Guideline “Cardiogenic shock – diagnosis, monitoring and therapy.”

New means of intervention – The broader therapeutic spectrum within cardiology
A substantial number of new methods have emerged within interventional cardiology in recent years. Many patients for whom there would have been no care just a few years ago due to the complexity of any operation are now admitted to heart catheter laboratories to receive successful interventional treatment there.

Therapeutic Goal
Besides rapid revascularisation, the aim of treating cardiogenic shock is to achieve haemodynamic management to ensure organ perfusion and adequate myocardial protection.

The Solution:
Integration of myocardial protection and organ perfusion

Medical Need
Challenges

  • severely restricted myocardial pump function
  • inadequate organ perfusion
  • SIRS, risk of multiple organ failure
  • more frequent multimorbidity among patients
  • better coronary perfusion
  • improved renal perfusion
  • improved cerebral perfusion
  • positive influence on the vascular system
  • improvements in microcirculation

Synchronized Cardiac Assist closes the gap between physiology and mechanical circulatory support
Synchronized Cardiac Assist is a new physiological method that adapts to the patient’s heart rhythm and helps support blood circulation.

  • physiological circulation support method
  • pulsatile, synchronous with the heart rhythm
  • active diastolic augmentation

“Our results indicate that ECG-synchronized pulsatile extracorporeal flow using i-COR system improves left-ventricular function and increases coronary flow in comparison with standard continuous-flow extracorporeal life support in cardiogenic shock.

Petr Ošťádal, MD, PhD
Cardiovascular Center, Na Homolce Hospital
Prague, Czech Republic

“Our findings suggest that pulsatile flow made possible by the novel i-cor system provides better preservation of renal function and systemic vascular tone and thus is suitable to partially support patients with respiratory and/or cardiac failure.”
Akif Undar, PhD
Penn State University
Hershey College of Medicine, Hershey, Pennsylvania USA

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