TAILORED TO EACH CHILDPATIENT’S
INDIVIDUAL NEEDS1

Our therapies for pediatric patients are focused exclusively on the pediatric and neonatal fields, and answer the specific need with a broad product portfolio for the full spectrum of extracorporeal pulmonary and cardiac support.

This specific Novalung and Medos product portfolio directly addresses the particular challenges associated with the treatment of this young and diverse group of patients.

1 Speth, Marlene et al. (2016) Pediatric extracorporeal life support using a third generation diagonal pump. ASAIO J. 62(4):482-490: p.482.

“The use of the Deltastream DP3 seems to be safe and effective for Mechanical Circulatory Support in children and might show a low degree of hemolysis. We observed no system-related complications and an overall good outcome in this demanding patient cohort.”

Fleck, Thilo; Benk, Christoph; Klemm, Rolf; Kroll, Johannes; Siepe, Matthias; Grohmann, Jochen; Höhn, René; Humburger, Frank; Beyersdorf, Friedhelm; Stiller, Brigitte (2013), European Journal of Cardio-Thoracic Surgery

Mastering particular challenges associated with this young and diverse group of patients

DIFFERENT TYPES OF PATIENTS – FROM NEONATES UP TO YOUNG ADULTS

SOLUTION
  • Different patient kits: Wide range of preconfigured or customized patient kits, tailored to the needs of the pediatric patient population
  • Xenios console as one platform and pump (DP3) offer the full range of support

Reference
„The low priming volume (16 mL), wide range of flow rate (0–8 L/min), rotation speed (0–10,000 rpm), and production of pressures up to 600 mm Hg allow it to be used in both pediatric and adult patients”2

„Increased flow range offers a higher level of fl exibility and safety for a wide range of applications”2

„In conclusion, the DP3 can be used for individual patient demands and adapted to their most suitable method of support. Meticulous flow adjustments render this pump highly effective for extracorporeal support particularly in pediatric patients.”1

1 Speth, Marlene et al. (2016) Pediatric extracorporeal life support using a third generation diagonal pump. ASAIO J. 62(4):482-490: p.482.
2 Okan, Yildiz et al. (2017) Initial Clinical Experiences With Novel Diagonal ECLS System in Pediatric Cardiac Patients. Artifi cal Organs 41(8):717-726: p.718.

OPPORTUNITY TO USE EXTRACORPOREAL SUPPORT AS LONG AS NEEDED

SOLUTION
  • Novalung patient kits certified for 29 days application period

Reference
“We used the same ECLS system for up to two weeks without changing it”3

“[…] enabled intensive care specialists to use VV-ECMO not only as a short-term rescue procedure, but also as a long-term application and bridge to transplantation in adult as well as pediatric patients.”4

“Within the development and introduction of longrunning ECMO devices (including heparin coated tubing, special microfiber polymethylpentene membranes, rotating blood pumps, and percutaneous catheters) with week-long stability […]”5

3 Okan, Yildiz et al. (2017) Initial Clinical Experiences With Novel Diagonal ECLS System in Pediatric Cardiac Patients. Artifi cal Organs 41(8):717-726: p.722.
4 Schmidt, Florian et al. (2012) Concept of “awake venovenous extracorporeal membrane oxygenation” in pediatric patients awaiting lung transplantation. Pediatric Transplantation. p.1.
5 Schmidt, Florian et al. (2012) Concept of “awake venovenous extracorporeal membrane oxygenation” in pediatric patients awaiting lung transplantation. Pediatric Transplantation. p.5.

Special Demands for Neonatal Patients

SOLUTION
  • DP3 pump allows flow adjustment in steps of 10 ml/min (requires ¼” patient kit and ¼” flow sensor)
  • Reduced turbulence because of continuous tubing diameter
  • Integrated Pressure Sensor (IPS) attributed for less hemodilution, reduced risk of air aspiration and clotting in pediatric patient

Reference
“It was shown that calculated low flow rates needed for support particularly in neonates can be maintained over a long period of time.”6

“Critical elements of construction related to the whole system are the connecting tubes, which conically increase from the venous ¼ inch to 3/8 inch at the pump entrance. This may predispose to turbulent flow and thrombus formation.”6

6 Speth, Marlene et al. (2016) Pediatric extracorporeal life support using a third generation diagonal pump. ASAIO J. 62(4):482-490: p.489.

Special Patient Group – Reacting More Sensitive to Any Change in Setting, Therapy or Parameter

SOLUTION
  • Xenios console provides several safety features for example bubble detection
  • One platform and pump (DP3) offer the full range of support
  • Possiblility to connect a heater cooler unit to the circuit for temperature management

Reference
“Safety functions are ensured by several control systems: cannula aspiration is prevented by preload control; a brief interruption of the flow can be managed with the zeroflow mode without risking backflow.”7

“[…] it is the prevention of backflow and features for pressure, bubble and flow control offering fine adjustmentsdown to zero, which make the DP3 safe.”6

“The system was complemented with an MDC console, which included valuable safety mechanisms such as a flow sensor with an integrated bubble detector, backflow detection, and temperature sensors.”2

2 Okan, Yildiz et al. (2017) Initial Clinical Experiences With Novel Diagonal ECLS System in Pediatric Cardiac Patients. Artifical Organs 41(8):717-726: p.718.
6 Speth, Marlene et al. (2016) Pediatric extracorporeal life support using a third generation diagonal pump. ASAIO J. 62(4):482-490: p.489.
7 Stiller, Brigitte et al (2017) Multicenter Experience With Mechanical Circulatory Support Using a New Diagonal Pump in 233 Children. Artficial Organs. p.3.

For further information, please contact your local Xenios AG representative.